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601608. 40 3. 39 293 5. 4 ± 53. terms of their principal effectors and sensitivity to Pertussis toxin (Ptx, which ADP- ribosylates a C-terminal cysteine present in certain α-subunits and prevents receptor coupling): (1) GsGolf-activate adenylate cyclase; not inhibited by Ptx; (2) GiGo inhibit adenylate cyclase andor modulate certain Ca2 and K chan- Binarj (via βγ-subunits); inhibited by Ptx; Ratiny GqG11, G14, G1516-activate PLCβ (β1,3,4); not inhibited by Ptx; (4) G1213multiple downstream targets; Rting inhibited by Ptx.

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